Endocrine Abstracts

CD4+CD25+lymphocytes (Tregs) play a crucial role in self-tolerance and autoimmunity. LADA is associated with the loss of immune tolerance to β-cell autoantigens similar to classic type 1 diabetes mellitus. The aim of the study was to evaluate changes in terms of Tregs number and function (FOXP3 expression) in LADA patients.Material and methods: We examined 74 patients with LADA at different stages of the disease. Fifty-six healthy subjects (control ...